| UniProtKB AC (Name) | UniProtKB Section | Organism | Description | |
|---|---|---|---|---|
| P0C058 (IBPB_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Small heat shock protein IbpB; 16 kDa heat shock protein B; | |
| P77397 (MHPA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase; | |
| P77329 (HYFG_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Hydrogenase-4 component G; | |
| P05824 (RECN_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | DNA repair protein RecN; Recombination protein N; | |
| P17444 (BETA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Oxygen-dependent choline dehydrogenase; Betaine aldehyde dehydrogenase; | |
| P77319 (HSCC_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Chaperone protein HscC; Hsc62; | |
| Q46795 (YGEO_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Putative uncharacterized protein YgeO; | |
| P77136 (YQEK_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YqeK; | |
| P52006 (NUDI_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Nucleoside triphosphatase NudI; Nucleotide diphosphatase NudI; Pyrimidine deoxynucleoside triphosphate diphosphatase; dCTP diphosphatase; dTTP diphosphatase; dUTP diphosphatase; | |
| P75680 (INSO1_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Putative transposase InsO for insertion sequence element IS911A; | |
| P0AB96 (ARSC_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Arsenate reductase; Arsenical pump modifier; | |
| P0AAA9 (ZRAP_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Zinc resistance-associated protein; | |
| P0AF63 (NSRR_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | HTH-type transcriptional repressor NsrR; | |
| P33231 (LLDP_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | L-lactate permease; | |
| P33595 (SGRR_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | HTH-type transcriptional regulator SgrR; | |
| P28904 (TREC_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Trehalose-6-phosphate hydrolase; Alpha,alpha-phosphotrehalase; | |
| P25549 (ASLA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Putative sulfatase AslA; | |
| P32710 (NRFE_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Probable cytochrome c-type biogenesis protein NrfE; | |
| P75828 (YBJD_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YbjD; | |
| P77510 (DPIB_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Sensor histidine kinase DpiB; Sensor histidine kinase CitA; | |
| P60872 (YIDE_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Putative transport protein YidE; | |
| P25798 (FLIF_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Flagellar M-ring protein; | |
| P0ADR0 (YQAA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Inner membrane protein YqaA; | |
| P0AAB8 (USPD_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Universal stress protein D; | |
| P46888 (USPC_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Universal stress protein C; | |
| P39177 (USPG_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Universal stress protein UP12; Universal stress protein G; | |
| P77306 (YQIK_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Flotillin family inner membrane protein YqiK; | |
| Q9S4W7 (YUBI_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Putative antirestriction protein YubI; | |
| P0C243 (YUBJ_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YubJ; | |
| P76041 (GGAP_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Glucosylglycerate phosphorylase; | |
| P0ADU7 (YQIB_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YqiB; | |
| P76485 (YFBO_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YfbO; | |
| P0AD47 (YPHA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Inner membrane protein YphA; | |
| P76064 (YDAT_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YdaT; | |
| Q46839 (GLCA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Glycolate permease GlcA; | |
| P25772 (LIGB_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | DNA ligase B; Polydeoxyribonucleotide synthase [NAD(+)] B; | |
| P0DP90 (ILVG_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Acetolactate synthase isozyme 2 large subunit; ALS-II; Acetohydroxy-acid synthase II large subunit; | |
| P32705 (ACTP_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Cation/acetate symporter ActP; Acetate permease; Acetate transporter ActP; | |
| P76463 (YFAQ_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YfaQ; | |
| P32703 (YJCE_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized Na(+)/H(+) exchanger YjcE; | |
| P62601 (TREF_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Cytoplasmic trehalase; Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase; | |
| P76473 (ARNT_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase; 4-amino-4-deoxy-L-arabinose lipid A transferase; Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase; Polymyxin resistance protein PmrK; Undecaprenyl phosphate-alpha-L-Ara4N transferase; | |
| P0AG27 (YIBN_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YibN; | |
| P39363 (SGCA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Putative phosphotransferase IIA component SgcA; Putative PTS system EIIA component; | |
| P0ADJ8 (YIAA_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Inner membrane protein YiaA; | |
| P41442 (GSPG_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Type II secretion system core protein G; Protein transport protein HofG; Putative general secretion pathway protein G; | |
| Q9S4X0 (YUBF_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Uncharacterized protein YubF; | |
| P36938 (PGM_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Phosphoglucomutase; Glucose phosphomutase; | |
| P0A6A0 (UBIB_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Probable protein kinase UbiB; Ubiquinone biosynthesis protein UbiB; | |
| P05704 (MCP3_ECOLI) | Swiss-Prot | Escherichia coli (strain K12) | Methyl-accepting chemotaxis protein III; Ribose and galactose chemoreceptor protein; |
Escherichia coli is a Gram negative gammaproteobacterium commonly found in the lower intestine of warm-blooded organisms (endotherms). Most E. coli strains are harmless and are part of the normal flora of the gut.
Since E. coli can survive outside the body for a limited amount of time, it is an indicator organism for fecal contamination of the environment. The descendants of two isolates, K-12 and B strain, are used routinely in molecular biology as both a tool and a model organism. It is the most widely studied prokaryotic model organism due to its ease of culturing and short generation time.
The first E. coli genome was sequenced in 1997 (K12 strain).
From left to right: i) The number of proteins in the reference proteome of Escherichia coli, ii) the number of unique protein sequences for which at least one model is available, iii) the total number of models and iv) a coverage bar plot is shown.
The bar plot shows the coverage for every protein in the reference proteome of Escherichia coli for which there is at least one model. Different colours (dark green to red boxes) represent the coverage of the targets. Targets with high coverage are represented in dark green (more than 80% of the target's length is covered by models), whereas low coverage is shown in red. The size of each box is proportional to the number of target sequences with a given coverage.
For information on the latest proteome for Escherichia coli, please visit UniProtKB.
You can easily download the latest protein sequences for Escherichia coli proteome here. Please note this download is for the current UniProtKB release, which may be different to release 2024_02 that was used for the most up to date SWISS-MODEL Repository.
| Proteins in proteome | Sequences modelled | Models |
| 4,403 | 3,676 | 6,176 |
Detailed coverage numbers are obtained by hovering the mouse over one of the boxes.
The plot shows the evolution over years (x-axis) of the fraction of Escherichia coli reference proteome residues (y-axis) for which structural information is available. Different colors (light blue to dark blue) in the plot represent the quality of the sequence alignment between the reference proteome sequences (targets) and the sequences of the proteins in the structure database (templates). Alignments with low sequence identity are displayed in light blue, whereas alignments with high sequence identity are depicted in dark blue. The SWISS-MODEL Template Library is used as database of templates. Only target-template alignments found by HHblits and only residues with atom coordinates are considered.
This chart shows the percentage of residues in the Escherichia coli proteome which are covered by experimental structures and the enhancement of coverage by homology modelling by the SWISS-MODEL pipeline. Experimental residue coverage is determined using SIFTS mapping. For residues which are not covered by experimental structures (including where there are no atom records in SIFTS mapping) the model coverage bars are coloured by QMEANDisCo local quality score.
Many proteins form oligomeric structures either by self-assembly (homo-oligomeric) or by assembly with other proteins (hetero-oligomeric) to accomplish their function. In SWISS-MODEL Repository, the quaternary structure annotation of the template is used to model the target sequence in its oligomeric form. Currently our method is limited to the modelling of homo-oligomeric assemblies. The oligomeric state of the template is only considered if the interface is conserved.
| Single Chain | 2-mer | 3-mer | 4-mer | 5-mer | 6-mer | 7-mer | 8-mer | 9-mer | 10-mer | 11-mer | 12-mer | 14-mer | 15-mer | 16-mer | 22-mer | 24-mer | 25-mer | 26-mer | 30-mer | 33-mer | 34-mer | 40-mer | 44-mer | 48-mer | 55-mer | 60-mer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3,649 | 1,628 | 137 | 467 | 19 | 137 | 10 | 58 | 4 | 19 | 2 | 14 | 4 | 1 | 1 | 2 | 12 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 |